Control of meningococcal meningitis with meningococcal vaccines.

Immunological Aspect of Meningococcal disease: An overview in Host- Bacteria Interaction

Meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. Meningococcal disease has a rapid onset with high mortality. The understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

Use of fractional doses of meningococcal polysaccharide vaccines for the control of epidemic meningococcal meningitis in Africa in a context of vaccine shortage

1 Meningococcal Vaccines : Current Status and 2 Emerging Strategies 3

Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis 8 is a public health burden to both developed and developing countries throughout the world. There 9 are a number of vaccines (polysaccharide-based, glycoconjugate, protein-based and combined 10 conjugate vaccines) that are approved to target five of the six disease-causing serogroups of the 11 pathogen. ...

Present situation and new perspectives for vaccination against Neisseria meningitidis in Tuscany, Central Italy.

BACKGROUND In Italy one third of bacterial meningitis are caused by Neisseria meningitidis. In March 2005, the Regional Health Authority of Tuscany included the meningococcal serogroup C conjugate (MCC) vaccine in the recommended vaccination program with a schedule of three doses to all newborns at 3, 5 and 13 months of age (from 2008 amended to a single dose at 13 months) and a single catch-up...

An evaluation of emerging vaccines for childhood meningococcal disease

BACKGROUND Meningococcal meningitis is a major cause of disease worldwide, with frequent epidemics particularly affecting an area of sub-Saharan Africa known as the "meningitis belt". Neisseria meningitidis group A (MenA) is responsible for major epidemics in Africa. Recently W-135 has emerged as an important pathogen. Currently, the strategy for control of such outbreaks is emergency use of me...